Any Duquesne University undergraduate student obtaining a degree in a school other than the College of Liberal Arts can earn a second major in any of the College of Liberal Arts majors. Likewise, any undergraduate student can pursue a second major in African Studies.

Students pursuing the second major must complete the University Core Curriculum, the core curriculum of the School in which the primary major resides, the curriculum requirements of the primary major, and the curriculum requirements of the second major in the College of Liberal Arts or in African Studies.