Contact Information

Biography

Dr. Seaman attained his graduate degree from Yale University, concentrating his dissertation research on gorillas' population genetics, phylogeny, and taxonomy. He furthered his expertise through post-doctoral research at the University of Chicago and the Medical College of Wisconsin, delving into molecular evolution and genomics. His academic journey began at the University of Wisconsin, where he earned his undergraduate degree. Currently, Dr. Seaman shares his knowledge through teaching introductory General Biology, Human Genetics, and Forensic Human Genetics, while also actively leading a research lab where he oversees both graduate and undergraduate students in their projects. Additionally, he serves as the co-director of Undergraduate Studies for the Department of Biological Sciences.

Central to the Seaman lab's research pursuits is the exploration of molecular evolution, with a primary focus on humans and other primates. A cornerstone of their investigations lies in understanding the impact of sexual selection on the genetic architecture and genomes of these species. Leveraging computational methodologies and empirical laboratory techniques, they identify potential adaptive changes and scrutinize hypotheses concerning protein functionality across diverse species.

The Seaman lab maintains a broader interest in molecular evolution, encompassing the dynamic evolution of gene families and various facets of genome evolution in primates. Through their multifaceted approach, they contribute to the ongoing exploration of evolutionary processes that shape life on Earth.

Education

  • Post-Doc, Genomics, Medical College of Wisconsin
  • Post-Doc, Ecology & Evolution, University of Chicago
  • Ph.D., Biological Anthropology, Yale University
  • B.S., Anthropology, University of Wisconsin
  • B.S., Molecular Biology, University of Wisconsin

Research Interests

  • Research Focus:

    • Investigating the genetic underpinnings of phenotypic changes in primate evolution.
    • Emphasis on recent evolution in humans, chimpanzees, and gorillas.
    • Exploring pronounced anatomical, behavioral, and physiological differences among closely related species.
    • Uncovering gene-level changes responsible for these differences, particularly those related to reproductive physiology.

  • Genome Evolution Studies:

    • Analysis of nuclear insertions of mitochondria DNA (numts) in hominoid primates.
    • Exploration of gene duplications, novel gene formation, and their impact on phenotypic adaptation.

  • Funding Support:

    • National Science Foundation
    • National Institutes of Health
    • Winters Foundation
    • Hunkele Dreaded Disease Foundation
    • Charles Henry Leach II Foundation
    • Wenner-Gren Foundation for Anthropological Research

School

About

  1. Das R, Hergenrother SD, Soto-Calderón ID, Dew JL, Anthony NM, Jensen-Seaman MI (2014) Complete mitochondrial genome sequence of the eastern gorilla (Gorilla beringei) and implications for African ape biogeography. Journal of Heredity. 105:752-761.
  2. Soto-Calderón ID, Clark NJ, Wildschutte Julia VH, DiMattio K, Jensen-Seaman MI, Anthony NM (2014) Identification of species-specific nuclear insertions of mitochondrial DNA (numts) in gorillas and their potential as population genetic markers. Molecular Phylogenetics and Evolution. 81:61-70.
  3. Carnahan-Craig SJ, Jensen-Seaman MI (2014) Rates of evolution of hominoid seminal proteins are correlated with function and expression, rather than mating system. Journal of Molecular Evolution. 78:87-99.
  4. Bishop AC, Ganguly S, Solis NV, Cooley BM, Jensen-Seaman MI, Filler SG. Mitchell AP, Patton-Vogt J (2013) Glycerophosphocholine utilization by Candida albicans: role of the Git3 transporter in virulence. Journal of Biological Chemistry. 288:33939-33952.
  5. Jensen-Seaman MI, Hooper-Boyd KA (2013) Molecular clocks: determining the age of the human-chimpanzee divergence. In: Encyclopedia of Life Sciences. John Wiley & Sons, Ltd: Chichester (UK) http://www.els.net
  6. Soto-Calderón ID, Lee EJ, Jensen-Seaman MI, Anthony NM (2012) Factors affecting the relative abundance of nuclear copies of mitochondrial DNA (numts) in hominoids. Journal of Molecular Evolution. 75:102-111.
  7. Maddalo G, Chovanec P, Stenberg-Bruzell F, Nielsen HV, Jensen-Seaman MI, Ilag LL, Kline KA, Daley DO (2011) A reference map of the membrane proteome of Enterococcus faecalis. Proteomics. 11: 3935-3941.
  8. Jensen-Seaman MI, Wildschutte JH, Soto-Calderón ID, Anthony NM (2009) A comparative approach shows differences in patterns of numt insertion during hominoid evolution. Journal of Molecular Evolution. 68: 688-699.
  9. Peppler AD and Jensen-Seaman MI (2009) Economical PCR-generated DNA ladder for agarose gels. Journal of the Pennsylvania Academy of Science. 83: 87-89.
  10. Carnahan SJ and Jensen-Seaman MI (2008)  Hominoid seminal protein evolution and ancestral mating behavior. American Journal of Primatology. 70: 939-948.
  11. Jensen-Seaman MI and Hooper-Boyd KH (2008) Molecular Clocks: Determining the Age of the Human-Chimpanzee Divergence. Encyclopedia of Life Sciences and Handbook of Human Molecular Evolution.
  12. Pazehoski KO, Collins T, Boyle RJ, Jensen-Seaman MI, and Dameron CT (2008) Stalking metal-linked dimers. Journal of Inorganic Biochemistry. 102: 522-531. 
  13. Schlick NE, Jensen-Seaman MI, Orlebeke K, Kwitek AE, Jacob HJ, and Lazar J (2006) Sequence analysis of the complete mitochondrial DNA in 10 commonly used inbred rat strains. American Journal of Physiology Cell Physiology. 291: C1183-1192.
  14. Jensen-Seaman MI, Sarmiento EE, Deinard AS, and Kidd KK (2004) Nuclear integrations of mitochondrial DNA in gorillas. American Journal of Primatology. 63: 139-147.
  15. Jensen-Seaman MI, Furey TS, Payseur BA, Lu Y, Roskin KM, Chen C-F, Thomas MA, Haussler D, and Jacob HJ (2004) Comparative recombination rates in the rat, mouse, and human genomes. Genome Research. 14: 528-538.
  16. Yu N*, Jensen-Seaman MI*, Chemnick L, Ryder O, and Li W-H (2004) Nucleotide diversity in gorillas. Genetics 166: 1375-1383. *equal contribution.
  17. Osoegawa K, Zhu B, Shu CL, Ren T, Cao Q, Vessere GM, Lutz MM, Jensen-Seaman MI, Zhao S, de Jong PJ (2004) BAC resources for the rat genome project. Genome Research. 14: 780-785.
  18. Vitt U, Gietzen D, Stevens K, Wingrove J, Becha S, Bulloch S, Burrill J, Chawla N, Chien J, Crawford M, Ison C, Kearney L, Kwong M, Park J, Policky J, Weiler M, White R, Xu Y, Daniels S, Jacob H, Jensen-Seaman MI, Lazar J, Stuve L, Schmidt J (2004) Identification of candidate disease genes by EST alignments, synteny, and expression and verification of Ensembl genes on rat chromosome 1q43-54. Genome Research. 14: 640-650.
  19. Rat Genome Sequencing Project Consortium (2004) Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 428: 493-521.
  20. Jensen-Seaman MI and Li W-H (2003) Molecular evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. Journal of Molecular Evolution. 57: 261-270.
  21. Jensen-Seaman MI, Deinard AS, and Kidd KK (2003) Mitochondrial and nuclear DNA estimates of divergence between western and eastern gorillas. In: Taylor AB and Goldsmith ML (eds.) Gorilla Biology: a multidisciplinary perspective. Cambridge University Press.
  22. Yu N, Jensen-Seaman MI, Chemnick C, Kidd JR, Deinard AS, Ryder O, Kidd KK, and Li W-H (2003) Low Nucleotide Diversity in Chimpanzees and Bonobos. Genetics. 164:1511-1518.
  23. Thomas MA, Chen C-F, Jensen-Seaman MI, Tonellato PJ, Twigger S (2003) Phylogenetics of rat inbred strains. Mammalian Genome 14: 61-64.
  24. Jensen-Seaman MI and Kidd KK (2001) Mitochondrial DNA variation and biogeography of eastern gorillas. Molecular Ecology 10: 2241-7.
  25. Jensen-Seaman MI, Deinard AS, Kidd KK (2001) Modern African ape populations as genetic and demographic models of the last common ancestor of humans, chimpanzees, and gorillas. Journal of Heredity 92: 475-80.
  26. Barbulescu M, Turner G, Su M, Kim R, Jensen-Seaman MI, Deinard AS, Kidd KK, and Lenz J (2001) A HERV-K provirus in chimpanzees, bonobos and gorillas, but not humans. Current Biology 11: 779-783.
  27. Turner G, Barbulescu M, Su M, Jensen-Seaman MI, Kidd KK, and Lenz J (2001) Insertional polymorphisms of full-length endogenous retroviruses in humans. Current Biology 11: 1531-1535.
  28. Seaman MI, Chang F-M, Quiñones A, Deinard AS, and Kidd KK (2000) Evolution of exon one of the dopamine D4 receptor (DRD4) gene in primates. Journal of Experimental Zoology (Molecular and Developmental Evolution). 288: 32-38.
  29. Seaman MI, Fisher JB, Chang F-M, and Kidd KK (1999) A Tandem duplication polymorphism upstream of the dopamine D4 receptor (DRD4). American Journal of Medical Genetics (Neuropsychiatric Genetics). 88: 705-709.
  30. Barbulescu M, Turner G, Seaman MI, Deinard AS, Kidd KK, and Lenz J (1999) Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans. Current Biology 9: 861-868.
  31. Iyengar SA*, Seaman M*, Deinard AS, Rosenbaum HC, Sirugo S, Castiglione CM, Kidd JR, and Kidd KK (1998) Analyses of cross-species PCR products to infer the ancestral state of human polymorphisms. DNA Sequence 8: 317-327.* equal contribution
  • Louis Leakey Foundation Award (2024-2025), "Evolutionary functional analysis of male reproductive proteins in primates"
  • Henry Charles Leach II Foundation (2020-2022), “Variation in expression of the relaxin gene and susceptibility to preterm birth”
  • NIH/National Institute of General Medicine, R15GM123447 (2017-2022), “Molecular basis of adaptation of seminal proteins of humans and other primates”
  • Outstanding Mentor Award for Excellence in Advising Graduate Students, 2022
  • Excellence in Teaching Award, School of Science & Engineering, Duquesne University, 2023
  • Biology I: Cells, Genetics, & Development (Biol 111)
    This course is a study of living systems at the molecular, cellular, and multicellular levels. It provides an introduction to cell chemistry, cell structure and function, energetics, and inheritance.
  • Human Genetics (Biol 468/568)
    This is an advanced course in human genetics focusing on principles of inheritance, structure and function of the human genome, molecular pathology, genetic mapping of diseases, and patterns of human genetic diversity.
  • Forensic Human Genetics (Biol 577)
    This course covers various aspects of human genetics, with an emphasis on applications to forensic science. Topics include cytogenetics, Mendelian inheritance, population genetics, and pattern of human diversity. This course is intended for fourth- or fifth-year students in the Forensic Science & Law program.